Astrocytes and neurons: different roles in regulating adenosine levels.
Identifieur interne : 002998 ( Main/Exploration ); précédent : 002997; suivant : 002999Astrocytes and neurons: different roles in regulating adenosine levels.
Auteurs : Fiona E. Parkinson [Canada] ; Wei Xiong ; Christina R. ZamzowSource :
- Neurological research [ 0161-6412 ] ; 2005.
English descriptors
- KwdEn :
- Adenosine (metabolism), Affinity Labels (pharmacology), Animals, Astrocytes (metabolism), Brain Ischemia (metabolism), Cells, Cultured, Deoxyglucose (pharmacology), Dipyridamole (pharmacology), Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Glucose (deficiency), Hypoxia (metabolism), Inosine (pharmacology), Models, Biological, Neurons (metabolism), Oligomycins (pharmacology), Phosphodiesterase Inhibitors (pharmacology), Prosencephalon (cytology), Purines (metabolism), Rats, Thioinosine (analogs & derivatives), Thioinosine (pharmacology), Tritium (metabolism).
- MESH :
- chemical , analogs & derivatives : Thioinosine.
- chemical , deficiency : Glucose.
- chemical , metabolism : Adenosine, Purines, Tritium.
- chemical , pharmacology : Affinity Labels, Deoxyglucose, Dipyridamole, Inosine, Oligomycins, Phosphodiesterase Inhibitors, Thioinosine.
- cytology : Prosencephalon.
- metabolism : Astrocytes, Brain Ischemia, Hypoxia, Neurons.
- Animals, Cells, Cultured, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Models, Biological, Rats.
Abstract
Adenosine is an endogenous nucleoside that signals through G-protein coupled receptors. Extracellular adenosine is required for receptor activation and two pathways have been identified for formation and cellular release of adenosine. The CLASSICAL pathway relies on intracellular formation of adenosine from adenine nucleotides and cellular efflux of adenosine via equilibrative nucleoside transporters (ENTs). The ALTERNATE pathway involves cellular release of adenine nucleotides, hydrolysis via ecto-5'-nucleotidases and extracellular formation of adenosine.
DOI: 10.1179/016164105X21878
PubMed: 15829178
Affiliations:
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Le document en format XML
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Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, A203-753 McDermot Avenue, Winnipeg MB Canada R3E 0T6. parkins@ms.umanitoba.ca</nlm:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Xiong, Wei" sort="Xiong, Wei" uniqKey="Xiong W" first="Wei" last="Xiong">Wei Xiong</name></author><author><name sortKey="Zamzow, Christina R" sort="Zamzow, Christina R" uniqKey="Zamzow C" first="Christina R" last="Zamzow">Christina R. Zamzow</name></author></analytic><series><title level="j">Neurological research</title><idno type="ISSN">0161-6412</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine (metabolism)</term><term>Affinity Labels (pharmacology)</term><term>Animals</term><term>Astrocytes (metabolism)</term><term>Brain Ischemia (metabolism)</term><term>Cells, Cultured</term><term>Deoxyglucose (pharmacology)</term><term>Dipyridamole (pharmacology)</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Drug Interactions</term><term>Glucose (deficiency)</term><term>Hypoxia (metabolism)</term><term>Inosine (pharmacology)</term><term>Models, Biological</term><term>Neurons (metabolism)</term><term>Oligomycins (pharmacology)</term><term>Phosphodiesterase Inhibitors (pharmacology)</term><term>Prosencephalon (cytology)</term><term>Purines (metabolism)</term><term>Rats</term><term>Thioinosine (analogs & derivatives)</term><term>Thioinosine (pharmacology)</term><term>Tritium (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Thioinosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Glucose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine</term><term>Purines</term><term>Tritium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Affinity Labels</term><term>Deoxyglucose</term><term>Dipyridamole</term><term>Inosine</term><term>Oligomycins</term><term>Phosphodiesterase Inhibitors</term><term>Thioinosine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Prosencephalon</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Astrocytes</term><term>Brain Ischemia</term><term>Hypoxia</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Drug Interactions</term><term>Models, Biological</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Adenosine is an endogenous nucleoside that signals through G-protein coupled receptors. Extracellular adenosine is required for receptor activation and two pathways have been identified for formation and cellular release of adenosine. The CLASSICAL pathway relies on intracellular formation of adenosine from adenine nucleotides and cellular efflux of adenosine via equilibrative nucleoside transporters (ENTs). The ALTERNATE pathway involves cellular release of adenine nucleotides, hydrolysis via ecto-5'-nucleotidases and extracellular formation of adenosine.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Xiong, Wei" sort="Xiong, Wei" uniqKey="Xiong W" first="Wei" last="Xiong">Wei Xiong</name><name sortKey="Zamzow, Christina R" sort="Zamzow, Christina R" uniqKey="Zamzow C" first="Christina R" last="Zamzow">Christina R. Zamzow</name></noCountry><country name="Canada"><noRegion><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. 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